Cyclic estradiol treatment modulates the orexigenic effects of ghrelin in ovariectomized rats
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چکیده
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Estradiol modulates Kiss1 neuronal response to ghrelin.
Ghrelin is a metabolic signal regulating energy homeostasis. Circulating ghrelin levels rise during starvation and fall after a meal, and therefore, ghrelin may function as a signal of negative energy balance. Ghrelin may also act as a modulator of reproductive physiology, as acute ghrelin administration suppresses gonadotropin secretion and inhibits the neuroendocrine reproductive axis. Intere...
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Background & Aims: Adult neurogenesis occurs in the two main areas of the brain of most mammalian species in; sub ventricular zone, and the dentate gyrus of the hippocampus. Many factors such as 17-β estradiol affect neurogenesis in the hippocampus. The aim of this study was to investigate the effect of exogenous 17-β estradiol on neurogenesis in the ovariectomized (OVX) mice. Materials & Meth...
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Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol.
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2014
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2014.07.004